HCID 86622537, compound → HCID 178467375, compound

HRID 1361922Notes

Reaction equation

C(C1N(CC2C=CC(C3C=CC=CC=3C3N(C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)N=NN=3)=CC=2)C(C(OC(OC(=O)CCC[C@@H](O[N+]([O-])=O)CO[N+]([O-])=O)C)=O)=C(Cl)N=1)CCC.[CH2:69]([O:71][C:72]1[N:76]([CH2:77][C:78]2[CH:83]=[CH:82][C:81]([C:84]3[CH:89]=[CH:88][CH:87]=[CH:86][C:85]=3[C:90]3[N:94](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:93]=[N:92][N:91]=3)=[CH:80][CH:79]=2)[C:75]2[C:114]([C:118]([O:120][CH:121]([O:123][C:124](=[O:138])[CH2:125][CH2:126][CH2:127][C@@H:128]([O:134][N+:135]([O-:137])=[O:136])[CH2:129][O:130][N+:131]([O-:133])=[O:132])[CH3:122])=[O:119])=[CH:115][CH:116]=[CH:117][C:74]=2[N:73]=1)[CH3:70]>>[CH2:69]([O:71][C:72]1[N:76]([CH2:77][C:78]2[CH:79]=[CH:80][C:81]([C:84]3[CH:89]=[CH:88][CH:87]=[CH:86][C:85]=3[C:90]3[NH:91][N:92]=[N:93][N:94]=3)=[CH:82][CH:83]=2)[C:75]2[C:114]([C:118]([O:120][CH:121]([O:123][C:124](=[O:138])[CH2:125][CH2:126][CH2:127][C@@H:128]([O:134][N+:135]([O-:137])=[O:136])[CH2:129][O:130][N+:131]([O-:133])=[O:132])[CH3:122])=[O:119])=[CH:115][CH:116]=[CH:117][C:74]=2[N:73]=1)[CH3:70]

Participants

Reactant 2

HCID 86622537HCID 86622537, compound

HCID 86622538HCID 86622538, compound

Product 1

HCID 178467375HCID 178467375, compound

Procedure

The title compound was prepared by following step D in example 14, except that the reagent 1-{[(5R)-5,6-bis(nitrooxy)hexanoyl]oxy}ethyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate was replaced by the individual diastereomerically pure 1-{[(5R)-5,6-bis(nitrooxy)hexanoyl]oxy}ethyl 2-ethoxy-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate.

Sources & evidence

ORD record: ord-0794db34c2d742b7bdec8715a0c4018e
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07880014B2

Reaction notes

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