Formic Acid → 6-Bromo-4H-imidazo[4,5-b]pyridine

HRID 1361935Notes

Reaction equation

HRID 1361935 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[CH:10][NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 6911565-Bromopyridine-2,3-diamine

Product 1

HCID 9115786-Bromo-4H-imidazo[4,5-b]pyridine

Procedure

5-Bromo-2,3-diaminopyridine (1.69 g, 8.99 mmole) was taken up in 96% formic acid (50 mL) and heated to reflux. After 18 hr the mixture was cooled to RT and concentrated. The residue was taken up in H2O and the pH was adjusted to 7 with 2.0 M NaOH. The title compound (1.54 g, 87%) was collected as a solid by filtration, washed with H2O, and dried in vacuo: MS (ES) m/e 198/200 (M+H)+.

Workup

  1. temperatureheated to reflux
  2. concentrationconcentrated
  3. filtrationThe title compound (1.54 g, 87%) was collected as a solid by filtration
  4. washwashed with H2O
  5. customdried in vacuo

Sources & evidence

ORD record
ord-fdc1f67de69546509f667c87926a98dc
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

Loading…