HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl acrylate → 1-ethyl-3-(methylaminomethyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl acrylate | HCID 15458 | — |
| Reactant | 3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl)-1-benzyl-1H-indole | HCID 22139015 | — |
| Reactant | 3-[N-(benzyloxycarbonyl)-N-methylaminomethyl]-1-ethyl-1H-indole | HCID 22139150 | — |
| Product | 1-ethyl-3-(methylaminomethyl)-1H-indole | HCID 22139101 | 94.8% |
Reaction Steps
According to the procedure of Preparation 17 (c), except substituting 3-[N-(benzyloxycarbonyl)-N-methylaminomethyl]-1-ethyl-1H-indole (0.90 g, 2.80 mmole) for the 3-[N-(benzyloxycarbonyl)-N-methylaminomethyl]-1-benzyl-1H-indole, the title compound (0.50 g, 94%) was prepared as a white solid: MS (ES) n/e 189 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879872B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-81a238ec062943829a44344cf5b488ce |
| Source note | uspto-grants-2011_02 |