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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1361963Generated: October 28, 2026

tert-Butyl acrylate → 1-ethyl-3-(methylaminomethyl)-1H-indole

https://huagongshe.com/reaction/1361963

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl acrylateHCID 15458—
Reactant3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl)-1-benzyl-1H-indoleHCID 22139015—
Reactant3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl]-1-isopropyl-1H-indoleHCID 22139078—
Product1-ethyl-3-(methylaminomethyl)-1H-indoleHCID 2213910187.3%

Reaction Steps

According to the procedure of Preparation 17 (c), except substituting 3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl]-1-isopropyl-1H-indole (0.99 g, 2.98 mmole) for the 3-[N-(Benzyloxycarbonyl)-N-methylaminomethyl]-1-benzyl-1H-indole, the title compound (0.49 g, 82%) was prepared as a white solid: MS (ES) ml/e 405 (2M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07879872B2
Source datasetuspto-grants-2011_02
ORD IDord-748bc235fd5d43618fbfc8326717c7ff
Source noteuspto-grants-2011_02