HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 5-Bromo-2-(methylaminocarbonylmethyl)aminopyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Methyl 2-((5-bromopyridin-2-yl)amino)acetate | HCID 22139049 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-Bromo-2-(methylaminocarbonylmethyl)aminopyridine | HCID 22139097 | 100% |
Reaction Steps
A solution of 2.0 M methylamine in MeOH (75 mL) was added to 5-bromo-2-(methoxycarbonylmethyl)aminopyridine (2.9 g, 12 mmole). The reaction was stirred for 24 h then was concentrated to dryness. The residue was triturated with 10% petroleum ether/Et2O (100 mL), then was collected and dried under vacuum to give the title compound (2.96 g, 100%) as an off-white solid: MS (ES) m/e 244.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07879872B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-fdd2b362e2a74a79adea3218a0dc673f |
| Source note | uspto-grants-2011_02 |