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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1361983Generated: October 26, 2026

Ethyl indole-2-carboxylate → 5-fluoro-1-methyl-1H-indole-3-carbaldehyde

https://huagongshe.com/reaction/1361983

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl indole-2-carboxylateHCID 73125—
Reactant5-fluoro-1H-indole-3-carbaldehydeHCID 259089—
Product5-fluoro-1-methyl-1H-indole-3-carbaldehydeHCID 138200950%

Reaction Steps

According to the procedure of Preparation 9 (a), except substituting 5-fluoro-1H-indole-3-carboxaldehyde (0.3 g, 1.8 mmole) for the ethyl indole-2-carboxylate, the title compound (0.16 g, 50%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07879872B2
Source datasetuspto-grants-2011_02
ORD IDord-bdd95ea46f684e56b350d52250163e65
Source noteuspto-grants-2011_02