1,3-dimethyl-1H-indole-2-carboxylate → HCID 22138996, compound

HRID 1361992Notes

Reaction equation

HRID 1361992 reaction equation
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[CH3:14][N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:24])[C:17]([C:25]([O-])=O)=[CH:16]1.CN1C2C(=CC=CC=2)C(C)=C1C([O-])=O>>[CH3:14][N:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][C:22]=2[CH3:24])[C:17]([CH2:25][NH:6][CH3:5])=[CH:16]1

Participants

4

Reactant 3

HCID 221390101,3-dimethyl-1H-indole-2-carboxylateHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139074HCID 22139074, compound

Product 1

HCID 22138996HCID 22138996, compoundYield 98%

Procedure

According to the procedure of Preparation 13 (c), except substituting 1,7-dimethyl-1H-indole-3-carboxylate for the 1,3-dimethyl-1H-indole-2-carboxylate, the title compound (0.74 g, 98%) was obtained as an amber oil: MS (ES) m/e 189.2 (M+H)+.

Sources & evidence

ORD record
ord-ada6110ae4b74be382ba8ff9c49ecf4f
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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