1,3-dimethyl-1H-indole-2-carbaldehyde → HCID 22139138, compound

HRID 1361993Notes

Reaction equation

HRID 1361993 reaction equation
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[CH3:14][N:15]1[C:23]2[C:18](=[C:19]([O:24][CH3:25])[CH:20]=[CH:21][CH:22]=2)[C:17]([CH:26]=O)=[CH:16]1.CN1C2C(=CC=CC=2)C(C)=C1C=O>>[CH3:25][O:24][C:19]1[CH:20]=[CH:21][CH:22]=[C:23]2[C:18]=1[C:17]([CH2:26][NH:6][CH3:5])=[CH:16][N:15]2[CH3:14]

Participants

4

Reactant 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 221390384-Methoxy-1-methyl-1H-indole-3-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetate

Product 1

HCID 22139138HCID 22139138, compoundYield 95%

Procedure

According to the procedure of Preparation 13 (c), except substituting 1-methyl-4-methoxy-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (2.0 g, 95%) was obtained as a white solid: MS (ES) m/e 205.2 (M+H)+.

Sources & evidence

ORD record
ord-b4941c009e33489cb44819eebd476ee1
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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