1,3-dimethyl-1H-indole-2-carbaldehyde → HCID 22139054, compound

HRID 1362004Notes

Reaction equation

HRID 1362004 reaction equation
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH:25]=O)=[CH:18][N:19]2[CH3:24].CN1C2C(=CC=CC=2)C(C)=C1C=O>>[Cl:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH2:25][NH:6][CH3:5])=[CH:18][N:19]2[CH3:24]

Participants

4

Reactant 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 221391304-chloro-1-methyl-1H-indole-3-carboxaldehyde

Product 1

HCID 22139054HCID 22139054, compoundYield 78%

Procedure

According to the procedure of Preparation 13 (c), except substituting 4-chloro-1-methyl-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (1.75 g, 78%) was obtained as a yellow solid: MS (ES) m/e 209.0 (M+H)+.

Sources & evidence

ORD record
ord-d017998846d04f459b114081313101cd
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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