1,3-dimethyl-1H-indole-2-carbaldehyde → HCID 22139068, compound

HRID 1362007Notes

Reaction equation

HRID 1362007 reaction equation
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[CH2:14]([O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:30]=1[N:29]([CH3:31])[CH:28]=[C:27]2[CH:32]=O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.CN1C2C(=CC=CC=2)C(C)=C1C=O>>[CH2:14]([O:21][C:22]1[CH:23]=[CH:24][CH:25]=[C:26]2[C:30]=1[N:29]([CH3:31])[CH:28]=[C:27]2[CH2:32][NH:6][CH3:5])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetateHCID 22139063HCID 22139063, compound

Product 1

HCID 22139068HCID 22139068, compoundYield 88%

Procedure

According to the procedure of Preparation 13 (c), except substituting 7-benzyloxy-1-methyl-1H-indole-3-carboxaldehyde for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (3.7 g, 88%) was obtained as an oil: MS (ES) m/e 281.2 (M+H)+.

Sources & evidence

ORD record
ord-96fb88656f7b468fa4d5c56366adc9e6
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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