Skatole → 1,2,7-trimethyl-1H-indole

HRID 1362008Notes

Reaction equation

HRID 1362008 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:11].[CH3:12]C1C2C(=CC=CC=2)NC=1>>[CH3:12][N:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][C:5]=2[CH3:11])[CH:10]=[C:2]1[CH3:1]

Participants

3

Reactant 2

HCID 6736SkatoleHCID 2598352,7-dimethyl-1H-indole

Product 1

HCID 221390881,2,7-trimethyl-1H-indoleYield 87%

Procedure

According to the procedure of Preparation 13 (a), except substituting 2,7-dimethylindole for the 3-methylindole, the title compound (960 mg, 87%) was obtained as an oil: MS (ES) m/e 160.2 (M+H)+.

Sources & evidence

ORD record
ord-68cfdc1a1a444149be140d705891f560
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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