HCID 59456910, compound → HCID 59456937, compound

HRID 1362113Notes

Reaction equation

HRID 1362113 reaction equation
[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH2:6][N:7]1[CH2:12][C:11]2[CH:13]=[C:14](Br)[CH:15]=[N:16][C:10]=2[NH:9][C:8]1=[O:18])[CH3:2].BrC1C=N[C:24]2NC(=O)N(CCN(C)C)[CH2:28][C:23]=2[CH:22]=1>>[C:23]([O:19][C:4](=[O:3])/[CH:5]=[CH:6]/[C:14]1[CH:15]=[N:16][C:10]2[NH:9][C:8](=[O:18])[N:7]([CH2:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:19])[CH2:12][C:11]=2[CH:13]=1)([CH3:22])([CH3:24])[CH3:28]

Participants

3

Reactant 2

HCID 59456910HCID 59456910, compoundHCID 59456958HCID 59456958, compound

Product 1

HCID 59456937HCID 59456937, compoundYield 21%

Procedure

According to the procedure of Preparation 130(d), except substituting 3-(6-bromo-2-oxo-1,4-dihydro-2H-pyrido[2,3-d]pyrimidin-3-yl)propionic acid ethyl ester for the 6-bromo-3-(2-dimethylamino-ethyl)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one, the title compound (0.39 g, 21%) was prepared as a white solid: MS (ESI) m/e 376 (M+H)+.

Sources & evidence

ORD record
ord-e27f052136854a1fafa8acbafda8c3c7
Source dataset
uspto-grants-2011_02
Patent number
US07879872B2

Reaction notes

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