(3-Chloro-7-fluoro-benzo[b]thiophen-2-yl)methanol → 3-Chloro-7-fluoro-benzo[b]thiophene-2-carbaldehyde

Participants

Reaction Steps

A suspension of (3-chloro-7-fluoro-benzo[b]thiophen-2-yl)methanol (600 g, 2.78 mmol) and MnO2 (1.69 g, 19.5 mmol) in benzene (25 mL) was stirred at room temperature for 2 d. The solution was filtered through diatomaceous earth and the filtrate concentrated to give the title compound (610 mg, quantitative) as a light, yellow solid: 1H NMR (300 MHz, CDCl3) δ 10.35 (s, 1H), 7.83 (d, J=8.1 Hz, 1H), 7.51 (ddd, J=8.0, 8.0, 4.8 Hz, 1H), 7.32-7.26 (m, 1H).

Provenance & Evidence