HCID 86602489, compound → 1-(2-Methylphenyl)ethan-1-amine

HRID 1362717Notes

Reaction equation

HRID 1362717 reaction equation
[N:1]([CH:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:12])[CH3:5])=[N+]=[N-].[H][H]>CO.[C].[Pd]>[C:7]1([CH3:12])[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=1[CH:4]([NH2:1])[CH3:5]

Participants

5

Reactant 2

HCID 86602489HCID 86602489, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 33910421-(2-Methylphenyl)ethan-1-amineYield 77.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

10% palladium-carbon (water content: 50%, 50 mg) was added to a solution of 1-(1-azidoethyl)-2-methylbenzene (744 mg) in methanol (5 mL), and the reaction solution was stirred in a hydrogen atmosphere at room temperature for 1 hour. The reaction solution was filtered on a celite, and the filtrate was concentrated under reduced pressure to obtain 482 mg of the title compound. The physical properties of the compound are as follows.

Workup

  1. filtrationThe reaction solution was filtered on a celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4e0725f6235046738b48e4099bba260f
Source dataset
uspto-grants-2011_02
Patent number
US07880009B2

Reaction notes

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