Sulfuric Acid → Lysine, DL-

HRID 1362818Notes

Reaction equation

HRID 1362818 reaction equation
S(=O)(=O)(O)O.[NH2:6][C@H:7]([C:13]([OH:15])=[O:14])[CH2:8][CH2:9][CH2:10][CH2:11][NH2:12]>>[CH2:9]([CH2:8][CH:7]([NH2:6])[C:13]([OH:15])=[O:14])[CH2:10][CH2:11][NH2:12]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 5962L-Lysine

Product 1

HCID 866Lysine, DL-

Procedure

The culture broth was adjusted to pH 3.0 with addition of sulfuric acid and then loaded on a cation exchange resin, DIAION SK1BL (Mitsubishi Chemical) so that L-lysine should be adsorbed on the resin. After the adsorption of L-lysine, the resin was washed with water, and L-lysine was eluted with aqueous ammonia. The eluent containing L-lysine was then concentrated in a rotatry evaporator until L-lysine concentration became 50% by weight to obtain an L-lysine base solution.

Workup

  1. washAfter the adsorption of L-lysine, the resin was washed with water, and L-lysine
  2. washwas eluted with aqueous ammonia
  3. additionThe eluent containing L-lysine
  4. concentrationwas then concentrated in a rotatry evaporator until L-lysine concentration

Sources & evidence

ORD record
ord-c3b18d2631ac43e394ca1eccadf1a4f8
Source dataset
uspto-grants-2011_02
Patent number
US07883878B2

Reaction notes

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