HCID 66924240, compound → HCID 66924233, compound

Participants

Reaction Steps

The title compound was prepared by using the same procedure as described for the preparation of 1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-7-[4-(piperidin-4-ylamino)-piperidin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid in Example 4, Step 3 except 7-(3-{[(1-tert-butoxycarbonyl-piperidin-4-yl)-(2-dimethylamino-ethyl)-amino]-methyl}-pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid was used in place of 7-[4-(1-tert-butoxycarbonyl-piperidin-4-ylamino)-piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid. The title compound was obtained as light yellow oil. ESI MS m/z 459 (M+H+); 1H NMR (400 MHz, CDCl3) δ 8.71 (s, 1H), 7.46 (d, .J=14.2 Hz, 1H), 4.11 (br s, 1H), 3.70 (m, 1H), 3.57 (m, 1H), 3.54 (s, 3H), 3.46 (m, 4H), 2.99 (m, 4H), 2.88 (m, 2H), 2.71 (s, 6H), 2.52 (m, 1H), 2.12 (q, J=5.5 Hz, 1H), 2.00 (dd, J=12.7 Hz, 19.4 Hz, 2H), 1.78 (q, J=11.6 Hz, 2H), 1.71 (q, J=8.4 Hz, 2H), 1.24 (m, 2H), 1.09-0.95 (m, 4H).

Provenance & Evidence