Hydrochloric Acid → HCID 58916975, compound

Participants

Reaction Steps

1.98 g 2-[(4-[1,2,4]Triazol-1-yl-phenoxy)-methyl]-2-benzylsulfonylamino-butyronitrile, 1.3 g potassium hydroxide, 4 drops of hydro-peroxide (30%) in 10 ml water are stirred for 18 hours at room temperature. After addition of 60 ml water the solution is acidified to pH 2 by addition of a 2 N hydrogen chloride solution and extracted with ethyl acetate. After evaporation of the solvent the residue is subjected to flash chromatography (eluant: ethyl acetate) to give 0.160 g of the product as white crystals. M.p. 195-198° C.

Provenance & Evidence