Isopropylamine → 2-Amino-6-fluoro-N-(1-methylethyl)benzamide

HRID 1362867Notes

Reaction equation

[F:1][C:2]1[C:7]2[C:8](=[O:13])OC(=O)[NH:11][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH:14]([NH2:17])([CH3:16])[CH3:15]>>[NH2:11][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([F:1])[C:7]=1[C:8]([NH:17][CH:14]([CH3:16])[CH3:15])=[O:13]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 27830576-Fluoroisatoic anhydride

Product 1

HCID 579741812-Amino-6-fluoro-N-(1-methylethyl)benzamide

Procedure

2-Amino-6-fluoro-N-(1-methylethyl)benzamide was prepared from 5-fluoro-2H-3,1-benzoxazine-2,4(1H)-dione and isopropyl amine following a procedure substantially as described for the preparation of Intermediate 25. MS: (M+H)+=197.

Sources & evidence

ORD record: ord-6f3a473ad7ee43099599eb5460bd08cf
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07884098B2

Reaction notes

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