HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Pyrrolidin-1-ylmethyl)aniline → 5-Bromo-2-[(5-chloro-2-{[3-(1-pyrrolidinylmethyl)phenyl]amino}-4-pyrimidinyl)amino]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Pyrrolidin-1-ylmethyl)aniline | HCID 1096407 | — |
| Reactant | 5-Bromo-2-[(2,5-dichloro-4-pyrimidinyl)amino]benzamide | HCID 57974190 | — |
| Product | 5-Bromo-2-[(5-chloro-2-{[3-(1-pyrrolidinylmethyl)phenyl]amino}-4-pyrimidinyl)amino]benzamide | HCID 57974163 | — |
Reaction Steps
5-Bromo-2-[(5-chloro-2-{[3-(1-pyrrolidinylmethyl)phenyl]amino}-4-pyrimidinyl)amino]benzamide was prepared by contacting 5-bromo-2-[(2,5-dichloro-4-pyrimidinyl)amino]benzamide (Intermediate 37) with 3-pyrrolidinylmethylaniline following a procedure substantially as described for the preparation of Example 1. Mass (M+H)+ 501, 503, 505
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884098B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-da5eea7ac70044d0a5ef9d27ff005f68 |
| Source note | uspto-grants-2011_02 |