反应详情

Ethyl 2-{[5-fluoro-2-({3-[2-(4-morpholinyl)ethyl]phenyl}amino)-4-pyrimidinyl]amino}benzoate (200 mg, 0.51 mmoles) and thiomorpholine (2 mL) were heated at 120° C. for 48 h. The reaction mixture was concentrated to dryness under vacuum and the title compound was purified by flash chromatography on silica gel (using ethyl acetate containing 0.1% triethylamine). MS: M(C27H31FN6O2S)=522.2, (M+H)+=523.

1. concentrationThe reaction mixture was concentrated to dryness under vacuum
2. customthe title compound was purified by flash chromatography on silica gel (using ethyl acetate containing 0.1% triethylamine)