反应详情

1-Benzyl-3-piperidone HCl salt hydrate (33 g, 0.135 mol) was suspended in methylene chloride (200 mL), and triethylamine (21 mL, 0.15 mol) was added to the suspension; which was stirred for three hours. The resultant mixture was washed with H2O (200 mL×2) and 300 mL of brine, then dried over magnesium sulfate, filtered, and the methylene chloride was removed to give 1-Benzyl-3-piperidone.

1. washThe resultant mixture was washed with H2O (200 mL×2) and 300 mL of brine
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered
4. customthe methylene chloride was removed