Triethylamine → 3-Piperidinone, 1-(phenylmethyl)-

HRID 1362923Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1362923
O.Cl.[CH2:3]([N:10]1[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH2:11]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(N(CC)CC)C>C(Cl)Cl>[CH2:3]([N:10]1[CH2:15][CH2:14][CH2:13][C:12](=[O:16])[CH2:11]1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 2

HCID 8471TriethylamineHCID 27608961-Benzylpiperidin-3-one hydrochloride hydrate

Produkt 1

HCID 966503-Piperidinone, 1-(phenylmethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1-Benzyl-3-piperidone HCl salt hydrate (33 g, 0.135 mol) was suspended in methylene chloride (200 mL), and triethylamine (21 mL, 0.15 mol) was added to the suspension; which was stirred for three hours. The resultant mixture was washed with H2O (200 mL×2) and 300 mL of brine, then dried over magnesium sulfate, filtered, and the methylene chloride was removed to give 1-Benzyl-3-piperidone.

Aufarbeitung

  1. washThe resultant mixture was washed with H2O (200 mL×2) and 300 mL of brine
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. customthe methylene chloride was removed

Quellen und Nachweise

ORD-Eintrag
ord-50a1f1bec61e4ba4a8f2185e0ee44fd5
Quelldatensatz
uspto-grants-2011_02
Patentnummer
US07884107B2

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