HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 6-Iodo-9-(2-trimethylsilanyl-ethoxymethyl)-9H-purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloromethyl 2-(trimethylsilyl)ethyl ether | HCID 2724271 | — |
| Reactant | HCID 178506563 | HCID 178506563 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Iodo-9-(2-trimethylsilanyl-ethoxymethyl)-9H-purine | HCID 57870812 | — |
Reaction Steps
405 mg (1.65 mmol) of 6-iodo-9H-purine was dissolved in 2 mL DMF. 72 mg (1.81 mmol) of 60% sodium hydride was added followed by 320 μL (1.81 mmol) of trimethylsilylethoxymethyl chloride. Yield: 343 mg of an oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884110B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-6ac6bde8850a48198aeb789a91453056 |
| Source note | uspto-grants-2011_02 |