Pyridine → 1-Cyclopropyl-7-fluoro-8-[4-(2-hydroxyethyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

HRID 136306Notes

Reaction equation

HRID 136306 reaction equation
[Cl:1][c:2]1[c:3]([F:23])[cH:4][c:5]2[c:6]([n:7][c:8]3[n:9]([CH:19]4[CH2:20][CH2:21]4)[cH:10][c:11]([C:16](=[O:17])[OH:18])[c:12](=[O:15])[c:13]3[cH:14]2)[cH:22]1.[OH:24][CH2:25][CH2:26][N:27]1[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]1.[cH:33]1[cH:34][cH:35][n:36][cH:37][cH:38]1>>[c:2]1([N:30]2[CH2:29][CH2:28][N:27]([CH2:26][CH2:25][OH:24])[CH2:32][CH2:31]2)[c:3]([F:23])[cH:4][c:5]2[c:6]([n:7][c:8]3[n:9]([CH:19]4[CH2:20][CH2:21]4)[cH:10][c:11]([C:16](=[O:17])[OH:18])[c:12](=[O:15])[c:13]3[cH:14]2)[cH:22]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 76771-(2-Hydroxyethyl)piperazineHCID 147005568-Chloro-1-cyclopropyl-7-fluoro-4-oxo-1,4-dihydro-benzo[b][1,8]naphthyridine-3-carboxylic acid

Product 1

HCID 147005771-Cyclopropyl-7-fluoro-8-[4-(2-hydroxyethyl)-1-piperazinyl]-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine-3-carboxylic acid

Sources & evidence

ORD record
ord-36f32f441cca4d6193d20e8dda69514d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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