HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chlorothiophene-2-carbonyl Chloride → HCID 57572393, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chlorothiophene-2-carbonyl Chloride | HCID 589223 | — |
| Reactant | HCID 57572395 | HCID 57572395 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57572393 | HCID 57572393 | — |
Reaction Steps
300 mg of tert-butyl 5-(3-amino-1H-indazol-5-yl)furan-2-carboxylate, 199 mg of 5-chlorothiophene-2-carbonyl chloride and 8 mg of 4-(dimethylamino)pyridine are stirred at 90° C. for 24 hours in 2 ml of pyridine and 100 μl of dioxane. The reaction mixture is evaporated, and the residue is purified by column chromatography. Yield: 260 mg (58%) of tert-butyl 5-{3-[(5-chlorothiophene-2-carbonyl)amino]-1H-indazol-5-yl}furan-2-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884126B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-c8e8ff20376f43459c256e76affaf733 |
| Source note | uspto-grants-2011_02 |