HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Amino-1,2,3,4-tetrahydroquinoline-6-carbonitrile, dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-Butyl (6-cyano-1,2,3,4-tetrahydroquinolin-3-yl)carbamate | HCID 66692977 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Amino-1,2,3,4-tetrahydroquinoline-6-carbonitrile, dihydrochloride | HCID 131728106 | 100% |
Reaction Steps
To a solution of 1C (546 mg, 2 mmol) in CH2Cl2 (5 mL) at 0° C. was added 4 M HCl in dioxane (4 mL, 16 mmol). After addition, the reaction mixture was stirred at RT for 2 h, then concentrated. The residue was stripped with ether (3×), and the resulting off-white solid dried in vacuo to afford the title compound (490 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884113B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-508a1093121c4f788c7f95ab440e4194 |
| Source note | uspto-grants-2011_02 |