Lithium hydroxide, monohydrate → HCID 59778157, compound

Participants

Reaction Steps

To a solution of 149C (825 mg, 2.27 mmol) in a mixed solvent of MeOH-THF-H2O (20 mL at ratio of 2:2:1) was added lithium hydroxide monohydrate (400 mg, 11.35 mmol). The mixture was stirred at RT for 2 h, then extracted with ether (20 mL). The aqueous layer was acidified to pH 4-5 using 3N aqueous HCl, then extracted with CH2Cl2 (3×). The combined CH2Cl2 extracts were washed with water, brine, dried Na2SO4), and concentrated in vacuo to afford compound 149D as light yellow foam (735 mg, 97%).

Provenance & Evidence