HCID 70798266, compound → HCID 46879420, compound

Participants

Reaction Steps

A 1:1 solution of TFA/DCM (10 mL) was added to tert-Butyl 9-(2,6-difluorobenzyl)-2-(6-cyano-1H-benzo[d]imidazol-1-yl)-8-oxo-8,9-dihydropurine-7-carboxylate (60) and stirred for 1 hr. The solvents were removed en vacuo and the resulting solid was triturated with Et2O, and suspended in 6N HCl. Removal of solvents and trituration with Et2O of the resulting solid gave the titled compound (61) (68 mg) as a HCl salt, MH+=404, 1H NMR (d6-DMSO) δ 11.8 (s, 1H), 9.2 (s, 1H), 8.8 (s, 1H), 8.0 (s, 1H), 7.9 (d, 1H), 7.8 (broad s, 1H), 7.4 (d, 1H), 7.4 (quintet, 1H), 7.1 (m, 2H), 5.2 (s, 2H) ppm, 19F NMR δ −114.3 (m).

Provenance & Evidence