Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 86610157 | HCID 86610157 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66970519 | HCID 66970519 | 66.2% |
Reaction Steps
To a solution of 2-chloro-N-(cis-3-methyl-tetrahydro-2H-pyran-4-yl)-5-nitropyrimidin-4-amine (115 mg) in acetonitrile (5 mL) was added potassium carbonate (300 mg) and benzimidazole (150 mg). The mixture was stirred at 70° C. for 2.5 hours. After diluting with 70 mL EtOAc, the mixture was washed with brine, dried over sodium sulfate, and concentrated in vacuo. Column chromatography (50→100% EtOAc/hexanes) provided 99 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07884109B2 |
|---|
| Source dataset | uspto-grants-2011_02 |
|---|
| ORD ID | ord-15bfd1b4571a487095a7a5a48eb2fc0f |
|---|
| Source note | uspto-grants-2011_02 |
|---|
