Trifluoroacetic acid methylene chloride → HCID 66970566, compound

HRID 1363172Notes

Reaction equation

HRID 1363172 reaction equation
C(O)(C(F)(F)F)=O.C(Cl)Cl.[F:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18]C(=O)OC(C)(C)C)=[C:14]([NH:26][C:27]2[N:35]=[C:34]3[C:30]([NH:31][C:32](=[O:47])[N:33]3[C@H:36]3[C:45]4[C:40](=[C:41]([F:46])[CH:42]=[CH:43][CH:44]=4)[O:39][CH2:38][CH2:37]3)=[CH:29][N:28]=2)[CH:13]=1>>[NH2:18][C:15]1[CH:16]=[CH:17][C:12]([F:11])=[CH:13][C:14]=1[NH:26][C:27]1[N:35]=[C:34]2[C:30]([NH:31][C:32](=[O:47])[N:33]2[C@H:36]2[C:45]3[C:40](=[C:41]([F:46])[CH:42]=[CH:43][CH:44]=3)[O:39][CH2:38][CH2:37]2)=[CH:29][N:28]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 66970432HCID 66970432, compound

Product 1

HCID 66970566HCID 66970566, compound

Procedure

A freshly prepared solution of 30% TFA/DCM (5 mL) was added to (R)-tert-butyl 4-fluoro-2-(9-(8-fluorochroman-4-yl)-8-oxo-8,9-dihydro-7H-purin-2-ylamino)phenylcarbamate and the solution was stirred at room temperature for 60 min then the solvents were removed in vacuo to yield (R)-2-(2-amino-5-fluorophenylamino)-9-(8-fluorochroman-4-yl)-7H-purin-8(9H)-one that was used as such MH+=411.

Workup

  1. customthe solvents were removed in vacuo

Sources & evidence

ORD record
ord-b6762f927c3147d4a99d5b91301caf04
Source dataset
uspto-grants-2011_02
Patent number
US07884109B2

Reaction notes

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