HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-tert-Butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate → (R)-N2-(2-amino-5-fluorophenyl)-N4-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-tert-Butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate | HCID 66970500 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | (R)-N2-(2-amino-5-fluorophenyl)-N4-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine | HCID 66970617 | — |
Reaction Steps
A freshly prepared solution of 30% TFA/DCM (100 mL) was added to (R)-tert-butyl 4-fluoro-2-(4-(8-fluorochroman-4-ylamino)-5-nitropyrimidin-2-ylamino)phenylcarbamate and the solution was stirred at room temperature for 60 min. The solvents were removed in vacuo to yield (R)—N2-(2-amino-5-fluorophenyl)-N4-(8-fluorochroman-4-yl)-5-nitropyrimidine-2,4-diamine that was carried on without further purification. MH+=415.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884109B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-e2fbb5d932234da690a0fb83edf1e1df |
| Source note | uspto-grants-2011_02 |