Sodium Dithionite → HCID 178508032, compound

Participants

Reaction Steps

A solution of trans-4-(2-(1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-ylamino)cyclohexanol (162 mg) in THF (20 ml) was treated with a solution of sodium hydrosulfite (500 mg) and NaHCO3 (500 mg) in 20 mL of water and stirred for 25 minutes. The mixture was diluted with 200 mL EtOAc and washed twice with saturated sodium chloride. The organic phase was dried over Na2SO4, filtered, and concentrated in vacuo to provide 150 mg of the title compound.

Provenance & Evidence