HCID 59846403, compound → (R)-7-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

Participants

Reaction Steps

(R)-1-azido-7-fluoro-1,2,3,4-tetrahydronaphthalene (4.85 g) was dissolved in methanol (70 mL) and mixed with Pd/C (10%, wet, 485 mg), applied to Parr apparatus under H2 (35 psi) overnight. The catalyst was removed by filtration and washed twice with MeOH. The filtrate and washings were combined and evaporated under reduced pressure to give a yellow oil product (3.82 g, 91%). 1H NMR (400 MHz, DMSO-d6) δ 7.28 (dd, 1H), 7.06 (t, 1H), 6.91 (m, 1H), 3.74-3.76 (m, 1H), 2.60-2.72 (m, 2H), 2.10 (broad, 2H), 1.80-1.90 (m, 2H), 1.45-1.67 (m, 2H). 19F NMR (400 MHz, DMSO-d6) δ −117.6.

Provenance & Evidence