Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodobenzene → 4-Phenylthiophene-3-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodobenzene | HCID 11575 | — |
| 반응물 | (4-Formylthiophen-3-yl)boronic acid | HCID 4190637 | — |
| 반응물 | 5-(4-Chlorobenzyl)thiophene-2-carbaldehyde | HCID 20161500 | — |
| 생성물 | 4-Phenylthiophene-3-carbaldehyde | HCID 15445887 | 48% |
반응 단계
The title compound was synthesized from iodobenzene and 4-formylthiophen-3-ylboronic acid using the conditions to synthesize 5-(4-chlorobenzyl)thiophene-2-carbaldehyde. Double elution by prep-TLC (10% heptane/DCM) allowed for the isolation of 4-phenylthiophene-3-carbaldehyde (300 mg, 48% yield). 1H NMR (400 MHz, CDCl3) δ ppm 7.32 (d, J=3.29 Hz, 1H), 7.39-7.50 (m, 5H), 8.27 (d, J=3.29 Hz, 1H), 9.87 (s, 1H); 13C NMR (100 MHz, CDCl3) δ 185.80, 143.82, 138.91, 134.68, 134.28, 129.30, 128.58, 128.05, 124.76.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07884124B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-8d50f8ebc1114348be1a6893a5b8b862 |
| 출처 메모 | uspto-grants-2011_02 |