4-Iodo-1-methylpyridin-2(1H)-one → 6-(3-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-[1-[4-(1-methyl-2-oxo-4-pyridinyl)phenyl]ethyl]-1,3-oxazinan-2-one

HRID 136329Notes

Reaction equation

HRID 136329 reaction equation
[F:1][c:2]1[cH:3][c:4]([C:8]2([CH2:32][C:33]([CH3:34])([CH3:35])[OH:36])[CH2:9][CH2:10][N:11]([CH:15]([CH3:16])[c:17]3[cH:18][cH:19][c:20]([B:23]4[O:24][C:25]([CH3:26])([CH3:27])[C:28]([CH3:29])([CH3:30])[O:31]4)[cH:21][cH:22]3)[C:12](=[O:14])[O:13]2)[cH:5][cH:6][cH:7]1.[I:37][c:38]1[cH:39][c:40](=[O:45])[n:41]([CH3:44])[cH:42][cH:43]1>>[F:1][c:2]1[cH:3][c:4]([C:8]2([CH2:32][C:33]([CH3:34])([CH3:35])[OH:36])[CH2:9][CH2:10][N:11]([CH:15]([CH3:16])[c:17]3[cH:18][cH:19][c:20](-[c:38]4[cH:39][c:40](=[O:45])[n:41]([CH3:44])[cH:42][cH:43]4)[cH:21][cH:22]3)[C:12](=[O:14])[O:13]2)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 534080094-Iodo-1-methylpyridin-2(1H)-oneHCID 178435621HCID 178435621, compound

Product 1

HCID 723443756-(3-Fluorophenyl)-6-(2-hydroxy-2-methylpropyl)-3-[1-[4-(1-methyl-2-oxo-4-pyridinyl)phenyl]ethyl]-1,3-oxazinan-2-one

Sources & evidence

ORD record
ord-6eb2eba3b7fb40f9886e75993f4fa401
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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