Sodium Hydroxide → HCID 14077195, compound

HRID 1363331Notes

Reaction equation

HRID 1363331 reaction equation
[OH-].[Na+].[CH3:3][N:4]1[CH2:8][CH2:7][C@@H:6]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])[C@@H:5]1[CH2:21][O:22]C(=O)C>CO>[CH3:3][N:4]1[CH2:8][CH2:7][C@@H:6]([C:9]2[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[CH:11][C:10]=2[O:19][CH3:20])[C@@H:5]1[CH2:21][OH:22]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131728659HCID 131728659, compound

Product 1

HCID 14077195HCID 14077195, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

A 10% aqueous NaOH solution (596 mL) was added to a solution of the compound of example 3 (241 g, 0.75 mol) in methanol (596 mL). The reaction mixture was stirred at 50° C. for 45 min. It was concentrated to a gum and then poured into ice-cold water (2 L). The resulting solid was filtered to obtain the title compound.

Workup

  1. concentrationIt was concentrated to a gum
  2. additionpoured into ice-cold water (2 L)
  3. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-3b4f9f1d9c3648f391a3bd08c11a5213
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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