反应详情

温度

50 °C

A 10% aqueous NaOH solution (596 mL) was added to a solution of the compound of example 3 (241 g, 0.75 mol) in methanol (596 mL). The reaction mixture was stirred at 50° C. for 45 min. It was concentrated to a gum and then poured into ice-cold water (2 L). The resulting solid was filtered to obtain the title compound.

1. concentrationIt was concentrated to a gum
2. additionpoured into ice-cold water (2 L)
3. filtrationThe resulting solid was filtered