反应详情

温度

180 °C

Molten pyridine hydrochloride (2.5 g, 21 mmol, 10×w/w) was added to compound of example 7 (0.25 g, 0.58 mmol) and heated at 180° C. for 1.5 h. The reaction mixture was cooled to 25° C., diluted with MeOH (10 mL) and basified using Na2CO3 to pH 10. The mixture was filtered and the organic layer was concentrated. The residue was suspended in water (10 mL), stirred for 30 min., filtered and dried to obtain the title compound.

1. temperatureThe reaction mixture was cooled to 25° C.
2. filtrationThe mixture was filtered
3. concentrationthe organic layer was concentrated
4. filtrationfiltered
5. customdried