Pyridinium chloride → HCID 66933916, compound

HRID 1363335Notes

Reaction equation

HRID 1363335 reaction equation
[OH:1][CH2:2][C@H:3]1[C@H:7]([C:8]2[C:9]([O:28]C)=[CH:10][C:11]([O:26]C)=[C:12]3[C:17]=2[O:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[I:24])=[CH:14][C:13]3=[O:25])[CH2:6][CH2:5][N:4]1[CH3:30].Cl.N1C=CC=CC=1>>[OH:26][C:11]1[CH:10]=[C:9]([OH:28])[C:8]([C@@H:7]2[CH2:6][CH2:5][N:4]([CH3:30])[C@H:3]2[CH2:2][OH:1])=[C:17]2[C:12]=1[C:13](=[O:25])[CH:14]=[C:15]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[I:24])[O:16]2

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66933654HCID 66933654, compound

Product 1

HCID 66933916HCID 66933916, compound

Procedure

Compound of example 18 (0.29 g, 0.588 mmol) subjected to demethylation using pyridine hydrochloride (3 g, 25.97 mmol) as described in example 17, afforded the title compound.

Sources & evidence

ORD record
ord-ead6bee37ac94d2d83fb09f869ca0614
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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