Pyridinium chloride → HCID 66933856, compound

HRID 1363344Notes

Reaction equation

HRID 1363344 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[O:11][C:12]2[C:17]([C:18](=[O:20])[CH:19]=1)=[C:16]([O:21]C)[CH:15]=[C:14]([O:23]C)[C:13]=2[C@@H:25]1[CH2:29][CH2:28][N:27]([CH3:30])[C@H:26]1[CH2:31][OH:32].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10]1[O:11][C:12]2[C:17]([C:18](=[O:20])[CH:19]=1)=[C:16]([OH:21])[CH:15]=[C:14]([OH:23])[C:13]=2[C@@H:25]1[CH2:29][CH2:28][N:27]([CH3:30])[C@H:26]1[CH2:31][OH:32]

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66933560HCID 66933560, compound

Product 1

HCID 66933856HCID 66933856, compound

Procedure

Compound of example 46 (0.53 g, 1.1 mmol) was subjected to demethylation using pyridine hydrochloride (5.5 g, 47.6 mmol) as described in example 17 to obtain the title compound.

Sources & evidence

ORD record
ord-381cf7ae8101452d864fba261bec7a0c
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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