2,3-Dihydroxybutanedioic Acid → HCID 66933855, compound

HRID 1363347Notes

Reaction equation

HRID 1363347 reaction equation
[C:1]([OH:10])(=[O:9])[CH:2]([CH:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[C:15]([F:19])=[CH:14][C:13]=1[C:20]1[O:21][C:22]2[C:27]([C:28](=[O:30])[CH:29]=1)=[C:26]([OH:31])[CH:25]=[C:24]([OH:32])[C:23]=2[C@@H:33]1[CH2:37][CH2:36][N:35]([CH3:38])[C@H:34]1[CH2:39][OH:40]>CO>[C:6]([CH:4]([CH:2]([C:1]([OH:10])=[O:9])[OH:3])[OH:5])([OH:8])=[O:7].[Cl:11][C:12]1[CH:17]=[C:16]([Cl:18])[C:15]([F:19])=[CH:14][C:13]=1[C:20]1[O:21][C:22]2[C:27]([C:28](=[O:30])[CH:29]=1)=[C:26]([OH:31])[CH:25]=[C:24]([OH:32])[C:23]=2[C@@H:33]1[CH2:37][CH2:36][N:35]([CH3:38])[C@H:34]1[CH2:39][OH:40]

Participants

4

Reactant 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 66933856HCID 66933856, compound

Product 1

HCID 66933855HCID 66933855, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
52.5 °C

Procedure

Tartaric acid (0.016 g, 0.11 mmol) was added to the suspension of compound of example 47 (0.05 g, 0.11 mmol) in methanol (2 mL). It was stirred for 10 min. at 50-55° C. The reaction mixture was concentrated and solid was dried to obtain the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customsolid was dried

Sources & evidence

ORD record
ord-abe2ab1dbce84994b814e94b28728657
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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