Maleic Acid → HCID 131728660, compound

HRID 1363348Notes

Reaction equation

HRID 1363348 reaction equation
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([F:17])=[CH:12][C:11]=1[C:18]1[O:19][C:20]2[C:25]([C:26](=[O:28])[CH:27]=1)=[C:24]([OH:29])[CH:23]=[C:22]([OH:30])[C:21]=2[C@@H:31]1[CH2:35][CH2:34][N:33]([CH3:36])[C@H:32]1[CH2:37][OH:38]>CO>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[C:13]([F:17])=[CH:12][C:11]=1[C:18]1[O:19][C:20]2[C:25]([C:26](=[O:28])[CH:27]=1)=[C:24]([OH:29])[CH:23]=[C:22]([OH:30])[C:21]=2[C@@H:31]1[CH2:35][CH2:34][N:33]([CH3:36])[C@H:32]1[CH2:37][OH:38]

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 66933856HCID 66933856, compound

Product 1

HCID 131728660HCID 131728660, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

Maleic acid (0.0127 g, 0.11 mmol) was added to the suspension of compound of example 47 (0.05 g, 0.11 mmol) in methanol (2 mL). It was stirred for 5 min. at 50° C. to get clear solution. The reaction mixture was concentrated and solid was dried to obtain the title compound.

Workup

  1. customto get clear solution
  2. concentrationThe reaction mixture was concentrated
  3. customsolid was dried

Sources & evidence

ORD record
ord-315efd72b93940dab9a7a53cbc20d087
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

Loading…