HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → (+)-trans-5,7-Dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-2-(4-trifluoromethyl-phenyl)-chromen-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | (+)-trans-8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-2-(4-trifluoromethyl-phenyl)-chromen-4-one | HCID 66933632 | — |
| Product | (+)-trans-5,7-Dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-2-(4-trifluoromethyl-phenyl)-chromen-4-one | HCID 66933731 | — |
Reaction Steps
Compound of example 64 (0.7 g, 1.51 mmol) was demethylated using pyridine hydrochloride (7 g, 60.60 mmol) as described in example 17 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884127B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-e4f19ee5eaf841a5be02ea5837097e75 |
| Source note | uspto-grants-2011_02 |