Pyridinium chloride → HCID 66933894, compound

HRID 1363359Notes

Reaction equation

HRID 1363359 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([O:19]C)[CH:13]=[C:12]([O:21]C)[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])[CH:5]=[CH:6][CH:7]=1.Cl.N1C=CC=CC=1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([OH:19])[CH:13]=[C:12]([OH:21])[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66933667HCID 66933667, compound

Product 1

HCID 66933894HCID 66933894, compound

Procedure

Compound of example 75 (0.51 g, 1.23 mmol) was demethylated using pyridine hydrochloride (5.1 g, 44.15 mmol) as described in example 17, gave the title compound.

Sources & evidence

ORD record
ord-50b0d7e41c7848368317530c7a98f45f
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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