Pyridinium chloride → HCID 66933760, compound

HRID 1363360Notes

Reaction equation

HRID 1363360 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([O:19]C)[CH:13]=[C:12]([O:21]C)[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])=[CH:4][CH:3]=1.Cl.N1C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([OH:19])[CH:13]=[C:12]([OH:21])[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66933658HCID 66933658, compound

Product 1

HCID 66933760HCID 66933760, compound

Procedure

Compound of example 77 (0.61 g, 1.29 mmol) was subjected to demethylation with pyridine hydrochloride (6.1 g, 52.81 mmol) as described in example 17, afforded the two title compounds which were separated using column chromatography.

Workup

  1. customafforded the two title compounds which
  2. customwere separated

Sources & evidence

ORD record
ord-7f321ea1e17b4cfca04c74d62cf36f47
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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