HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (+)-trans-4-[8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-4-oxo-4h-chromen-2-yl]-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 4-cyanobenzoate | HCID 70791 | — |
| Reactant | (-)-trans-1-[2-Hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-1-ethanone | HCID 59318484 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (+)-trans-4-[8-(2-Hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-4-oxo-4h-chromen-2-yl]-benzonitrile | HCID 66933662 | — |
Reaction Steps
Compound of example 6 (1.5 g, 4.85 mmol) in dry DMF (15 mL) reacted with methyl 4-cyanobenzoate (2.57 g, 17.2 mmol) in the presence of NaH (50%, 1.2 g, 25 mmol), as described example 16, afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884127B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-90dfccb49e1d4390b91c0e2aca7fe591 |
| Source note | uspto-grants-2011_02 |