HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 68881133, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Methyl 2-Methoxybenzoate | HCID 61151 | — |
| Reactant | (-)-trans-1-[2-Hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-1-ethanone | HCID 59318484 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68881133 | HCID 68881133 | — |
Reaction Steps
Compound of example 6 (0.7 g, 2.2 mmol) in dry DMF (10 mL) was reacted with methyl 2-methoxybenzoate (1.13 g, 6.8 mmol) in the presence of NaH (50%, 0.544 g, 11.3 mmol) as described in example 16 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884127B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-c5997c0b55ae46458cc117c57d4d3f67 |
| Source note | uspto-grants-2011_02 |