Pyridinium chloride → HCID 66934002, compound

HRID 1363367Notes

Reaction equation

HRID 1363367 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([O:19]C)[CH:13]=[C:12]([O:21]C)[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])=[C:4]([Cl:31])[CH:3]=1.Cl.N1C=CC=CC=1>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[C:15]([C:16](=[O:18])[CH:17]=2)=[C:14]([OH:19])[CH:13]=[C:12]([OH:21])[C:11]=3[C@@H:23]2[CH2:27][CH2:26][N:25]([CH3:28])[C@H:24]2[CH2:29][OH:30])=[C:4]([Cl:31])[CH:3]=1

Participants

3

Reactant 2

HCID 10176127Pyridinium chlorideHCID 66934116HCID 66934116, compound

Product 1

HCID 66934002HCID 66934002, compound

Procedure

Compound of example 99 (0.3 g, 0.59 mmol) was demethylated using pyridine hydrochloride (3 g, 26.0 mmol) as described in example 17 to obtain the title compound.

Sources & evidence

ORD record
ord-08314fbdd402411795177058d753b1cd
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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