HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → (+/-)-trans-2-(2-Chloro-5-dimethylamino-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (-)-trans-1-[2-Hydroxy-3-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-4,6-dimethoxyphenyl]-1-ethanone | HCID 59318484 | — |
| Reactant | Methyl 2-chloro-5-(dimethylamino)benzoate | HCID 66909163 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (+/-)-trans-2-(2-Chloro-5-dimethylamino-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one | HCID 131728661 | — |
Reaction Steps
Compound of example 6 (0.8 g, 2.58 mmol) in dry DMF (15 mL) was reacted with methyl-2 chloro-5-dimethylaminobenzoate (1.65 g, 7.7 mmol) in the presence of NaH (50%, 0.62 g, 12.9 mmol) as described in example 16 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884127B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-e9b7b4b4c5ee4ceaa5f15741e96a832e |
| Source note | uspto-grants-2011_02 |