HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridinium chloride → (+/-)-trans-2-(2-Chloro-5-methylamino-phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridinium chloride | HCID 10176127 | — |
| Reactant | (+/-)-trans-2-(2-Chloro-5-dimethylamino-phenyl)-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-5,7-dimethoxy-chromen-4-one | HCID 131728661 | — |
| Product | (+/-)-trans-2-(2-Chloro-5-methylamino-phenyl)-5,7-dihydroxy-8-(2-hydroxymethyl-1-methyl-pyrrolidin-3-yl)-chromen-4-one | HCID 131728662 | — |
Reaction Steps
Compound of example 101 (0.25 g, 0.53 mmol) was demethylated using pyridine hydrochloride (2.5 g, 21.6 mmol) as described in example 17 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07884127B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-2af92b7aa9f74a3e81fec1096485481e |
| Source note | uspto-grants-2011_02 |