Pyridinium chloride → HCID 131728669, compound

HRID 1363375Notes

Reaction equation

[NH2:1][CH2:2][C@H:3]1[C@H:7]([C:8]2[C:9]([O:28]C)=[CH:10][C:11]([O:26]C)=[C:12]3[C:17]=2[O:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])=[CH:14][C:13]3=[O:25])[CH2:6][CH2:5][N:4]1[CH3:30].Cl.N1C=CC=CC=1>>[NH2:1][CH2:2][C@H:3]1[C@H:7]([C:8]2[C:9]([OH:28])=[CH:10][C:11]([OH:26])=[C:12]3[C:17]=2[O:16][C:15]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[Cl:24])=[CH:14][C:13]3=[O:25])[CH2:6][CH2:5][N:4]1[CH3:30]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 131728667HCID 131728667, compound

Product 1

HCID 131728669HCID 131728669, compound

Procedure

Compound of example 108 (0.45 g, 1.0 mmol) was demethylated using pyridine hydrochloride (5.0 g, 43.0 mmol) as described in example 17 to obtain the title compound.

Sources & evidence

ORD record: ord-f48d5f0012da4874b625c8da1ae31660
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07884127B2

Reaction notes

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