Pyridinium chloride → HCID 131728678, compound

HRID 1363386Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([C:16](=[O:18])[CH:17]=1)=[C:14]([O:19]C)[CH:13]=[C:12]([O:21]C)[C:11]=2[C@@H:23]1[CH2:27][CH2:26][N:25]([C:28]2[CH:33]=[CH:32][C:31]([O:34]C)=[CH:30][CH:29]=2)[C@H:24]1[CH2:36][OH:37].Cl.N1C=CC=CC=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:9][C:10]2[C:15]([C:16](=[O:18])[CH:17]=1)=[C:14]([OH:19])[CH:13]=[C:12]([OH:21])[C:11]=2[C@@H:23]1[CH2:27][CH2:26][N:25]([C:28]2[CH:29]=[CH:30][C:31]([OH:34])=[CH:32][CH:33]=2)[C@H:24]1[CH2:36][OH:37]

Participants

Reactant 2

HCID 10176127Pyridinium chloride

HCID 131728677HCID 131728677, compound

Product 1

HCID 131728678HCID 131728678, compound

Procedure

Compound of example 124 (0.7 g, 1.3 mmol) was demethylated using pyridine hydrochloride (10.5 g, 90.9 mmol) as described in example 17 to obtain the title compound.

Sources & evidence

ORD record: ord-823e87e1508a4bc398352a129dc41dac
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07884127B2

Reaction notes

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